別府大学短期大学部紀要
(Bulletin of Beppu University Junior College).
No.38
(2019.
2)
,p.17-
23
識別番号
ISSN
02864991
DOI
URI
抄録
Thyroid-related hormones（TRHs）are involved in the regulation of endocrine function
and metabolic processes of the thyroid gland, and hyperthyroidism is known to cause
tremors, weight loss, and excessive sweating. As a part of examining the relationship between
TRHs and the metabolism of amino acid in the plasma, we analyzed the correlation
between TRHs and plasma levels of amino acids using samples from seven healthy
volunteers. We measured three types of TRHs: thyroid-stimulating hormone（TSH）, free
triiodothyronine（FT３）, and free thyroxine（FT４）in addition to ３９ different amino acidsincluding the ２０ proteinogenic amino acids in the plasma collected from the healthy volunteers.
We observed significant correlations between levels of taurine and FT４（p ＝
０．０１８）, valine and FT４（p ＝０．０４３）, citrulline and TSH（p ＝０．０１１）, and hydroxyproline
and TSH（p ＝０．０４９）. We also observed a correlation between the levels of citrulline and
hydroxyproline（p＝０．００７９）. These results suggest that the interaction between citrulline
and hydroxyproline may be involved in the plasma amino acid metabolism of TRHs.
